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NVP-BKM120 hydrochloride
CAS No. 1312445-63-8
NVP-BKM120 hydrochloride ( BKM-120 hydrochloride;Buparlisib hydrochloride )
Catalog No. M11254 CAS No. 1312445-63-8
A potent, selective, orally bioavailable inhibitor of class I PI3K isoforms.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 176 | Get Quote |
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| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameNVP-BKM120 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, orally bioavailable inhibitor of class I PI3K isoforms.
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DescriptionA potent, selective, orally bioavailable inhibitor of class I PI3K isoforms with IC50 of 52 nM/166 nM/116 nM/262 nM for p110α/β/δ/γ, respectively; much less effectively inhibits the class III PI3K Vps34 and mTOR, and has no effect on PI4Kβ and several other kinases; prevents the growth of assorted cancer cell lines when used at 5 μM and inhibits tumor growth in vivo.Blood Cancer Phase 2 Clinical
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SynonymsBKM-120 hydrochloride;Buparlisib hydrochloride
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorPI3K
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number1312445-63-8
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Formula Weight446.85
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Molecular FormulaC18H22ClF3N6O2
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESC1COCCN1C2=NC(=NC(=C2)C3=CN=C(C=C3C(F)(F)F)N)N4CCOCC4.Cl
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Chemical Name2-Pyridinamine, 5-(2,6-di-4-morpholinyl-4-pyrimidinyl)-4-(trifluoromethyl)-, hydrochloride (1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Maira SM, et al. Mol Cancer Ther. 2012 Feb;11(2):317-28.
2. Pei Y, et al. Cancer Cell. 2012 Feb 14;21(2):155-67.
3. Koul D, et al. Clin Cancer Res. 2012 Jan 1;18(1):184-95.
2. Pei Y, et al. Cancer Cell. 2012 Feb 14;21(2):155-67.
3. Koul D, et al. Clin Cancer Res. 2012 Jan 1;18(1):184-95.
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