Cart
sales@molnova.com
NVP-BKM120 hydrochloride
CAS No. 1312445-63-8
NVP-BKM120 hydrochloride ( BKM-120 hydrochloride;Buparlisib hydrochloride )
Catalog No. M11254 CAS No. 1312445-63-8
A potent, selective, orally bioavailable inhibitor of class I PI3K isoforms.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 176 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameNVP-BKM120 hydrochloride
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, selective, orally bioavailable inhibitor of class I PI3K isoforms.
-
DescriptionA potent, selective, orally bioavailable inhibitor of class I PI3K isoforms with IC50 of 52 nM/166 nM/116 nM/262 nM for p110α/β/δ/γ, respectively; much less effectively inhibits the class III PI3K Vps34 and mTOR, and has no effect on PI4Kβ and several other kinases; prevents the growth of assorted cancer cell lines when used at 5 μM and inhibits tumor growth in vivo.Blood Cancer Phase 2 Clinical
-
SynonymsBKM-120 hydrochloride;Buparlisib hydrochloride
-
PathwayPI3K/Akt/mTOR signaling
-
TargetPI3K
-
RecptorPI3K
-
Research AreaCancer
-
IndicationBlood cancer
Chemical Information
-
CAS Number1312445-63-8
-
Formula Weight446.85
-
Molecular FormulaC18H22ClF3N6O2
-
Purity>98% (HPLC)
-
Solubility10 mM in DMSO
-
SMILESC1COCCN1C2=NC(=NC(=C2)C3=CN=C(C=C3C(F)(F)F)N)N4CCOCC4.Cl
-
Chemical Name2-Pyridinamine, 5-(2,6-di-4-morpholinyl-4-pyrimidinyl)-4-(trifluoromethyl)-, hydrochloride (1:1)
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Maira SM, et al. Mol Cancer Ther. 2012 Feb;11(2):317-28.
2. Pei Y, et al. Cancer Cell. 2012 Feb 14;21(2):155-67.
3. Koul D, et al. Clin Cancer Res. 2012 Jan 1;18(1):184-95.
2. Pei Y, et al. Cancer Cell. 2012 Feb 14;21(2):155-67.
3. Koul D, et al. Clin Cancer Res. 2012 Jan 1;18(1):184-95.
molnova catalog
related products
-
AS-252424
AS-252424 is a potent and selective PI3Kγ inhibitor with an IC50 of 30±10 nM.
-
PF-04979064
A highly potent and selective, dual PI3K/mTOR inhibitor.
-
Loureirin A
Loureirin A has an inhibitory effect on platelet activation perhaps through an impairment of PI3K/Akt signaling.Loureirin A negatively affects agonist-induced platelet aggregation such as collagen collagen-related peptide (CRP) ADP and thrombin.
